ncRNA name | ANRIL |
ncRNA Category | lncRNA |
ID | 100048912 |
Ensembl | ENSG00000240498 |
Synonyms | CDKN2B-AS1, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, RP11-145E5.4, p15AS |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | human UM cell line OM431; human cutaneous melanoma cell line A375 |
Methods | Western blot, RT-PCR, knockdown, xenograft, immunohistochemistry, CCK-8 assay |
Expression pattern | up-regulated |
Functional description | ANRIL was overexpressed in both the cutaneous and uveal melanoma cohorts compared with the normal control cohort. In a suspicious INK4b-ARF-INK4a gene cluster at chromosome 9p21, aberrant INK4a and INK4b defects were simultaneously endogenously auto-corrected after targeting the suppression of abnormal ANRIL lncRNA. |
PubMed ID | 27461581 |
Year | 2016 |
Title | ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma. |
Drug-related ncRNA | NO |
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